Mac: Intel Macs and some PowerPC Macs running OS 8.6 or later. Please note, pre-2008 Intel Macs and non-Intel Macs will not be able to boot external enclosures that have over 2.2TB support enabled. This is a hardware limitation of the computer.

PC: Will boot as long as your BIOS supports booting from the FireWire 400 interface. BIOS support will vary by motherboard and host board adapters.